Almost one year after the release of v0.4.5, the ProbABEL development team is happy to announce the release of v0.5.0.
This release contains several important improvements and fixes and all users are encouraged to upgrade.
(Please click on "read more", below, for more details.)
Information on how to get the source code or binaries can be found on the ProbABEL page. Please note that since most people (if they use Windows for this type of analysis at all) run 64 bit Windows, we stopped providing 32 bit binaries.
The most important user-visible changes are:
pacoxphhave a new option:
--flipmaf. If this option is selected, ProbABEL will 'flip' the alleles A1 and A2 for those variants for which the Freq1 value in the info file is less than 0.5. Changing the reference and effect allele in this way can sometimes (for some genetic models and low MAF), reduce regression errors and thus result in proper estimates which otherwise be set to NaN. Many thanks for the group of Prof. Kiemeney at the dept. for Health Evidence Radboud UMC in Nijmegen (NL) for sponsoring the work on this feature! Also thanks to Tessel Galesloot from the same group for extensive testing of this release.
--interactionoption the incorrect was used.
--interaction_onlyoption has been removed. Thanks to Matthias Wuttke for reminding us of this bug.
For a full list of changes, see the
Thanks to all who made this release possible, by providing code patches, by being beta testers, by suggesting enhancements, or otherwise!